Wet cupping therapy (WCT) "Turks say hacamat along with other persian name is hijamat" is a straightforward and economic treatment that also needs scientific interpretation. It treated- Hacamat
effectively diseases with various etiologies and pathogeneses e.g. arthritis rheumatoid (RA), hypertension, migraine,
carpal tunnel (CTS), fibromyalgia, cellulitis yet others. Here, we review medical and scientific bases
underlying cupping therapy and introduce Taibah theory like a novel evidence-based scientific mechanism to spell out
it. Briefly, in Taibah theory, WCT is a minor surgical excretory procedure related scientifically for the principles of
renal glomerular filtration and abscess evacuation, in which a pressure-dependent excretion of causative pathological
substances (CPS) occurs. CPS include disease-causing substances and disease-related substances (that result
during disease pathogenesis). Negative pressure used on skin surface causes local number of filtered and
interstitial fluids containing CPS at skin upliftings inside cups. Scarifying skin upliftings accompanied by cupping causes
a pressure gradient plus a traction force across the skin and capillaries to excrete collected fluids with CPS and
cause bleeding at puncture sites. This increases filtration at both capillary ends to cause clearance of blood and
interstitial spaces from CPS. WCT advantages from the suction pressure, phenomenon of reactive hyperemia, n . o .
production and skin scarifications (openings in skin barrier) in enhancing natural excretory skin functions, improving
lymphatic and capillary circulations and restoring homeostasis. Reported CPS of RA include autoantibodies, immune
complexes, soluble interleukin-2 receptors, inflammatory mediators, certain cytokines, prostaglandins, toxic cellular
products and rheumatoid factor, while CPS of CTS include malondialdehyde, interleukin 6, prostaglandin PGE- 2
and progressive edema (causing pain). WCT-induced filtration pressure may excrete those CPS in cupped blood.
Prophetic medicine (in connection with Prophet Mohammad peace be upon him) recommends WCT: �The best among
whatever you use in therapy is Al-hijamah (prophetic way of WCT / hacamat tedavisi)�. In conclusion, WCT has scientific bases in
treating different diseases is the only treatment that clears blood and interstitial fluid from CPS.Therapeutic
benefits of WCT is related to the amount of excreted CPS not the amount of letted blood.